Electroencephalography (EEG) and Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) correlates of motor behaviour in children and adolescents with unilateral Cerebral Palsy (uCP): effects of intervention

Electroencephalography (EEG) and Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) correlates of motor behaviour in children and adolescents with unilateral Cerebral Palsy (uCP): effects of intervention - EEG & DTI in uCP * effects of intervention

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38974

Enrollment

Registered

2013-07-11

Start date

2014-06-23

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

unilateral Cerebral Palsy / spasticity

Interventions

Regular care

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: Main group: Children and adolescents with unilateral Cerebral Palsy (4-17 jaar) who are registered for either a modified Constraint Induced Movement Therapy (mCIMT- "piraten" group, n

Exclusion criteria

Exclusion criteria: Severe hearing or visual disability; inability to understand the task For MRI: presence of iron containing implants, pacemaker. Inability to keep immobile in a lying position for at least several minutes.

Design outcomes

Primary

Measure	Time frame
Main group: Event Related Potential (ERP) components from the ongoing EEG in reaction to different visual stimuli and consecutive motor responses (pressing a large button) during several simple tasks. Tasks are directed at the use of either the non-affected or the affected hand/arm. Results from stimulus-response pairs demanding the use of the non-affected hand will be compared with results from stimulus-response pairs demanding the use of the affected hand. In addition, results before and after intervention will be compared. Sub group: Anatomical integrity of the corticospinal tract will be measured by diffusion tensor DT-MRI and subsequent tractography of both ipsi- and contral-lateral hemispheres with respect to both the affected and non-affected hand/arm. These DTI measures (fractional anisotropy FA , mean diffusivity MD) will be compared with EEG/ERP parameters and clinical observation of the hand capacity. In addition, results before and after intervention will be compared.	—

Measure

Time frame

Main group: Event Related Potential (ERP) components from the ongoing EEG in reaction to different visual stimuli and consecutive motor responses (pressing a large button) during several simple tasks. Tasks are directed at the use of either the non-affected or the affected hand/arm. Results from stimulus-response pairs demanding the use of the non-affected hand will be compared with results from stimulus-response pairs demanding the use of the affected hand. In addition, results before and after intervention will be compared. Sub group: Anatomical integrity of the corticospinal tract will be measured by diffusion tensor DT-MRI and subsequent tractography of both ipsi- and contral-lateral hemispheres with respect to both the affected and non-affected hand/arm. These DTI measures (fractional anisotropy FA , mean diffusivity MD) will be compared with EEG/ERP parameters and clinical observation of the hand capacity. In addition, results before and after intervention will be compared.

—

Secondary

Measure	Time frame
Demographic variables including gender, age and co-morbidity.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)