Optimizing Transcranial Direct Current Stimulation for Motor Learning

Optimizing Transcranial Direct Current Stimulation for Motor Learning - Optimizing tDCS for Motor Learning

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON38970

Enrollment

330

Registered

2014-01-14

Start date

2014-08-27

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebrovascular accident Stroke

Interventions

Subjects receive real or sham tDCS over the motor cortex or cerebellum for at most 30 minutes with an intensity up to 2mA.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy Aged 18-55

Exclusion criteria

Exclusion criteria: History of neurological or psychiatric disorders History of neurosurgery Taking acute or chronic psychoactive drugs Alcoholism

Design outcomes

Primary

Measure	Time frame
The main objective of the study is to determine the effect of different tDCS parameters on motor learning in healthy individuals. As a paradigmatic motor learning task, we will use a well-described visuomotor adaptation paradigm during reaching movements. During these fast reaching movements, an unexpected 30-degree rotation is introduced which requires subjects to learn a new visuomotor transformation. Visuomotor adaptation performance will be quantied in each trial using the angular end point error, dened as the angle between the line connecting the starting position to the center of the target and the line connecting the starting position to the end point. Retention will be quantified as the rate of deadaptation without visual feedback. Thus, the goal of the study is to define specific parameters of tDCS stimulation that obtain the optimal stimulation configuration for achieving rapid adaptation and extended retention.	—

Measure

Time frame

The main objective of the study is to determine the effect of different tDCS parameters on motor learning in healthy individuals. As a paradigmatic motor learning task, we will use a well-described visuomotor adaptation paradigm during reaching movements. During these fast reaching movements, an unexpected 30-degree rotation is introduced which requires subjects to learn a new visuomotor transformation. Visuomotor adaptation performance will be quanti*ed in each trial using the angular end point error, de*ned as the angle between the line connecting the starting position to the center of the target and the line connecting the starting position to the end point. Retention will be quantified as the rate of deadaptation without visual feedback. Thus, the goal of the study is to define specific parameters of tDCS stimulation that obtain the optimal stimulation configuration for achieving rapid adaptation and extended retention.

—

Secondary

Measure	Time frame
To determine the main effect of each of the (isolated) tDCS parameters on motor learning in healthy individuals with regard to visuomotor adaptation rate and retention. To determine if interactions are present between the different tDCS parameters with regard to visuomotor adaptation rate and retention in healthy individuals. To determine the size of the interaction effects with regard to visuomotor adaptation rate and retention in healthy individuals. To determine if the presence of a common BDNF mutation modifies the effect of tDCS on visuomotor adaptation rate and retention. To determine the main effect of the BDNF mutation on motor learning with regard to visuomotor adaptation rate and retention. To determine the wash-out period (period of time in which the effects of tDCS are still present without stimulation) for tDCS effects on motor learning in healthy individuals with regard to visuomotor adaptation rate and retention.	—

Measure

Time frame

To determine the main effect of each of the (isolated) tDCS parameters on motor learning in healthy individuals with regard to visuomotor adaptation rate and retention. To determine if interactions are present between the different tDCS parameters with regard to visuomotor adaptation rate and retention in healthy individuals. To determine the size of the interaction effects with regard to visuomotor adaptation rate and retention in healthy individuals. To determine if the presence of a common BDNF mutation modifies the effect of tDCS on visuomotor adaptation rate and retention. To determine the main effect of the BDNF mutation on motor learning with regard to visuomotor adaptation rate and retention. To determine the wash-out period (period of time in which the effects of tDCS are still present without stimulation) for tDCS effects on motor learning in healthy individuals with regard to visuomotor adaptation rate and retention.

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)