Hymenoptera venom allergy insect venom allergy
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - A clear positive history of a systemic response grade IV or a large local reaction after a vespid sting* - Vespid specific serum IgE > 0.70 kUA/l or a positive intracutaneous skin test for vespid venom (at
Exclusion criteria
Exclusion criteria: - Age under 18 years - Incapacitated subjects - Conditions that influence the immune system (immune deficiencies, malignancy, auto-immune diseases) - Pregnancy (measured before inclusion by β-hCG) - Mastocytosis;Extra exclusion criteria for indicator subjects: - A positive history of a large local or systemic response after a Hymenoptera sting - Vespid specific serum IgE > 0.30 kUA/l
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CD63 and CD203c expression on basophils. | — |
Secondary
| Measure | Time frame |
|---|---|
| Detection and comparison of factors in supernatant of basophils from anaphylactically sensitized patients compared to non-anaphylactically sensitized patients. | — |
Countries
Netherlands
Outcome results
None listed