impaired fat metabolism Overweight
Conditions
Interventions
In total there will be three test days with a wash-out period of one week in
between. The interventions will be diluted into a high-fat milkshake.
The three test days consist of:
1. 13C inulin (500mg
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Overweight/obese men (BMI>=25kg/m2
Exclusion criteria
Exclusion criteria: - Type 2 diabetes mellitus (defined as FPG >= 7.0 mmol/l) - Gastroenterological diseases or abdominal surgery - Cardiovascular diseases, cancer, liver or kidney malfunction, disease with a life expectancy shorter then 5 years - Abuse of products - Plans to lose weight or following of a hypocaloric diet - Regular supplementation of pre- or probiotic products, use of pre- or probiotics 3 months prior to the start of the study - Intensive exercise training more than three hours a week - Use of any medication that influences glucose or fat metabolism and inflammation (i.e. NSAIDs). - Regular use of laxative products - Use of antibiotics 3 months prior to the start of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoint: Energy expenditure, fat and carbohydrate oxidation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints: - 13C incorporation in SCFA from labelled inulin in peripheral blood and faeces; - Plasma and fecal SCFA content after inulin ingestion; - Hormones that influence substrate and energy metabolism like Insulin, Glucagon, GLP-1, PYY, FIAF; - Circulating metabolites like Glucose, Free Fatty Acids, Triglycerides; - Inflammatory markers like TNF-a, IL-6, IL-1, Adipokines; - Indirect markers of insulin sensitivity like circulating insulin concentrations; - Breath sampling for 13CO2; - Adipose tissue and muscle gene/protein expression and inflammatory markers; - Appetite (VAS-scoring). | — |
Countries
Netherlands
Outcome results
None listed