Studies into the mechanism of measles-associated immune suppression during an outbreak of measles in The Netherlands

Studies into the mechanism of measles-associated immune suppression during an outbreak of measles in The Netherlands - How does measles cause immune suppression?

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38941

Enrollment

200

Registered

2013-07-11

Start date

2013-07-16

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Measles (Rubeola)

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Aged 4-17 years old - Unvaccinated against measles - No known history of natural measles

Exclusion criteria

Exclusion criteria: - Chronic disease - Immune suppression (due to medication or underlying disease)

Design outcomes

Primary

Measure	Time frame
Main study parameters/endpoints: The study consists of two cohorts. In cohort A clinical specimens (a blood sample and swabs of the upper respiratory tract) will be collected from children with an acute MV infection, shortly before, at or after onset of rash. The main study parameter in this group will be the characterization of MV-infected lymphocytes in peripheral blood, in order to confirm that the virus predominantly infects memory T- and B-lymphocytes. In cohort B blood samples will be collected from children that have not yet been exposed to MV. A second blood sample will be collected two to three weeks after recovery from measles. The main study parameter in this group will be the quantification of pre-existing memory lymphocyte populations in peripheral blood, to test the hypothesis that these cell populations are decimated during measles.	—

Measure

Time frame

Main study parameters/endpoints: The study consists of two cohorts. In cohort A clinical specimens (a blood sample and swabs of the upper respiratory tract) will be collected from children with an acute MV infection, shortly before, at or after onset of rash. The main study parameter in this group will be the characterization of MV-infected lymphocytes in peripheral blood, in order to confirm that the virus predominantly infects memory T- and B-lymphocytes. In cohort B blood samples will be collected from children that have not yet been exposed to MV. A second blood sample will be collected two to three weeks after recovery from measles. The main study parameter in this group will be the quantification of pre-existing memory lymphocyte populations in peripheral blood, to test the hypothesis that these cell populations are decimated during measles.

—

Secondary

Measure	Time frame
As a secondary objective, we will try to validate and translate observations from our animal model studies to natural measles virus infections in children. To this end, we will measure hematological, virological and immunological parameters in white blood cells, plasma and swabs of the upper respiratory tract.	—

Countries

Netherlands

Outcome results