Identification of premotor white matter tracts involved in language before and after resection of tumors in the left hemisphere.

Identification of premotor white matter tracts involved in language before and after resection of tumors in the left hemisphere. - Language tracts before and after resection of tumors.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38935

Enrollment

Registered

2013-09-10

Start date

2013-12-12

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

brain neoplasma brain tumor

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Right-handed adult patients 18 years and older with a intraparenchymal brain tumor in the left hemisphere without other neurological or psychiatric disorders.

Exclusion criteria

Exclusion criteria: Patients with more than one tumor. Patients who suffer from other specific neurological or psychiatric disorders than caused by the tumor will be excluded. Patients who cannot go in the MRI scanner are also excluded.

Design outcomes

Primary

Measure	Time frame
(1) Evaluation of the white matter tracts between Broca's area and the ventral premotor cortex with the SMA and Wernicke's area in the left hemisphere to assess if they can be identified. The mirrored equivalent in the right hemisphere functions as a reference. (2) To assess if there is a correlation between language dysfunction and tumor involvement of these connections. (3) Comparison of the volume of connections in the pre- and postoperative situation. (4) To assess if there is a relation between disruption of the specific SMA connections and motor dysfunction (especially bilateral tasks). Language dysfunction will be quantified with the Boston naming test, fluency tests (letter, semantic, verbs, spontaneous speech), the Token test (from the Aachen Aphasia test), object naming and action naming. Language tests will be correlated with the amount of white matter tracts between the areas of interest.	—

Measure

Time frame

(1) Evaluation of the white matter tracts between Broca's area and the ventral premotor cortex with the SMA and Wernicke's area in the left hemisphere to assess if they can be identified. The mirrored equivalent in the right hemisphere functions as a reference. (2) To assess if there is a correlation between language dysfunction and tumor involvement of these connections. (3) Comparison of the volume of connections in the pre- and postoperative situation. (4) To assess if there is a relation between disruption of the specific SMA connections and motor dysfunction (especially bilateral tasks). Language dysfunction will be quantified with the Boston naming test, fluency tests (letter, semantic, verbs, spontaneous speech), the Token test (from the Aachen Aphasia test), object naming and action naming. Language tests will be correlated with the amount of white matter tracts between the areas of interest.

—

Secondary

Measure	Time frame
The amount of resection of tumors. Neurological deficit. This is descriptive.	—

Countries

Netherlands

Outcome results