n.a. n.a.
Conditions
Interventions
tDCS (anodal, 2 mA, 15 minutes, three sessions) will be applied with three
different tDCS configurations targeting the motor cortical representation of
the right FDI muscle. Excitability is measured
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age 18-45 years Righthanded
Exclusion criteria
Exclusion criteria: • Epilepsy, convulsion or seizure (TMS) • Serious head trauma or brain surgery • Large or ferromagnetic metal parts in the head (except for a dental wire) • Implanted cardiac pacemaker or neurostimulator • Pregnancy • Skin diseases at intended electrode sites (EMG, tDCS) • History or current presence of any neurologic or psychiatric disease • Any prescribed medication that can alter cortical excitability (e.g. antiepileptics, tricyclic anti-depressives or benzodiazepines) or can have an influence on the participant*s vigilance or cognitive performance within two weeks prior to participation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This study will examine the changes in motor cortical excitability, defined as the size of MEPs measured via TMS and EMG, induced by anodal tDCS using different electrode configurations. Specifically, we predict that the model-based optimized configurations will lead to a larger increase in MEP size than the standard configuration from literature. | — |
Secondary
| Measure | Time frame |
|---|---|
| Furthermore, we expect that optimization based on both electric field strength and direction will lead to a larger increase in MEP size than optimization based on electric field strength alone. | — |
Countries
Netherlands
Outcome results
None listed