Microbiota inhabiting the small intestine in relation to glycaemic and inflammatory status of morbidly obese subjects.

Microbiota inhabiting the small intestine in relation to glycaemic and inflammatory status of morbidly obese subjects. - Microbiota inhabiting the small intestine in relation to diabetes

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38923

Enrollment

Registered

2013-12-12

Start date

2015-03-06

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes mellitus obesity

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - BMI> 40 or BMI> 35 kg/m2 with or without co-morbidities - undergoing hastric bypass surgery - Age 18-60 years (in line with the indication criteria for bariatric surgery) - Caucasian race (previous research showed that people of different ethnicity vary in intestinal microbiota composition)

Exclusion criteria

Exclusion criteria: - Age 60 years - Alcohol abuse (>10 standard international units/week) or any drug use (Cannabis, cocaine, etc) - Auto-immune and / or inflammatory diseases (eg sarcoidosis, diabetes mellitus type I, liver disease, or intestinal diseases such as inflammatory bowel disease) - Antibiotics usage

Design outcomes

Primary

Measure	Time frame
Microbiota composition: - adherent microbiota at site of ileum - luminary small intestinal microbiota composition - faecal microbiota composition Insulin resistance (plasma): - Glucose - Insulin - HbA1C Inflammation: - CRP (plasma) - histological staining	—

Secondary

Measure	Time frame
- BMI - Diet	—

Countries

Netherlands

Outcome results