ontwikkeling van hersenen (in relatie tot het te vroeg sluiten van schedelnaden) Craniosynostosis premature fusion of the skullsutures
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: Patients with one of the following diagnoses: - Complex craniosynostosis - Syndromic craniosynostosis - Trigonocephaly - Scaphocephaly And: - Between 0 and 2 years of age
Exclusion criteria
Exclusion criteria: Patients with any metallic object in their skull. Patients with a known allergy to the used anaesthetic agent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters follow from the MR scan outcomes. The cerebral blood flow will be measured in ml/g/min per region of the brain. DTI data is expressed in fractional anisotropy (FA) and Apparent Diffusion Coefficient (ADC) values for all regions of interest. The endpoint for the individual patient is reached after the last MR scan is made. Standard clinical follow-up will last until the patient is 18 years of age. | — |
Secondary
| Measure | Time frame |
|---|---|
| primary study parameters will be correlated to the outcome of neuro-cognitive test performed during standard clinical follow-up. | — |
Countries
Netherlands
Outcome results
None listed