gastrointestinal symptoms
Conditions
Interventions
Positioning of a feeding catheter, to be applied for fluid sampling from the
small intestine.
Blood sampling.
Sugar test (consumption of sugar drink and collection of urine) for the
assewssment of i
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: no gastrointestinal complaints age between 18 and 65 yrs BMI between 20 and 30 kg/m^2
Exclusion criteria
Exclusion criteria: Use of medication within 14 days prior to testing Administration of probiotics, investigational drugs, or participation in a scientific intervention study in the 180 days prior to testing Use of antibiotics in the 90 days prior to testing women; pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • Sugar recovery in urine, as indicator of intestinal permeability | — |
Secondary
| Measure | Time frame |
|---|---|
| - Measurements in blood at baseline and after the supplementation period • Biomarkers of immune modulation; plasma levels of TNFa, IL-1b, IL-6, IL-8, IL-17, MCP-1 and MIP-1a - Measurements in small intestinal fluid (duodenum/jejunum/ileum) and feces • Relative abundance of CRIB • Microbial diversity and population dynamics • In situ gene expression of the microbiota - Questionnaire at baseline, during and after the supplementation period • The symptom diary | — |
Countries
Netherlands
Outcome results
None listed