End Stage Renal Disease Hyperoxaluria
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: ESRD on dialysis or after renal transplantation OR hyperoxaluria, AND age >8 years
Exclusion criteria
Exclusion criteria: * Any co-morbidity causing bone disease, such as osteogenesis imperfecta, Marfan syndrome, Ehler Danlos, panhypopituitarism, malignancy and musculoskeletal disorders * Inability to perform adequate MR imaging, for example not being able to lie still * absolute contra-indications for MR imaging, such as metal in eyes, cardiac pacemakers, implanted cardioverter defibrillators, neurostimulation systems and cochlear implants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary objectives: - To asses the validity of microMRI in imaging trabecular and cortical bone - To asses the feasibility to diagnose ROD in pediatric ESRD with microMRI in an early stage - To asses the feasibility to diagnose oxalosis associated bone disease with microMRI | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objectives - To investigate the possibility to distinguish between high and low turnover bone disease in pediatric ESRD with microMRI - Compare microMRI with conventional radiography and/or DEXA scanning in children with ESRD - Compare microMRI with conventional radiography and/or DEXA scanning in patients suffering from oxalosis - Compare microMRI with pathological changes found in bone biopsies from adult ESRD patients who have clinical indication for bone biopsy | — |
Countries
Netherlands
Outcome results
None listed