FindTrial
Sign In

Calibration of extracellulair fluid volume measurement by 125I-iothalamate in subjects with a low GFR using Bromide distribution volume.

Calibration of extracellulair fluid volume measurement by 125I-iothalamate in subjects with a low GFR using Bromide distribution volume. - ECV-measurement by 125I-iothalamate in low GFR.

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON38842
Enrollment
50
Registered
2014-02-06
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic kidney disease stadium III and IV

Interventions

None listed

Sponsors

Universitair Medisch Centrum Groningen
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Undergoing renal function measurement with 125I-iothalamate during regular post transplant follow-up >= 1 year post-transplantation Age >=18 years GFR 30-60 ml/min for 25/50 subjects, for 25/50 subjects GFR

Exclusion criteria

Exclusion criteria: No understanding of the patient information No informed consent Underlying malignancy or infectious disease;For bio-impedance measurements: • Pacemaker or implantable cardioverter defibrillator (ICD) making bio-impedance measurements unreliable

Design outcomes

Primary

MeasureTime frame
The aim of this calibration study is the development of an empirical algorithm for calculation of the ECFV using VdIOT, that includes correction for the systematic error due to extrarenal clearance of 125I-iothalamate. To this purpose, the main study parameter is correlation of the distribution volumes of of 125I-iothalamate and Bromide in subjects with a GFR—

Secondary

MeasureTime frame
• Urinary clearance of 125I-iothalamate within 24 and 48 hours after administration in subjects with a GFR—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)