Psychoneurobiology of itch symptoms in patients following burn injuries: an explorative study

Psychoneurobiology of itch symptoms in patients following burn injuries: an explorative study - Psychoneurobiology of post-burn itch

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38819

Enrollment

Registered

2013-11-21

Start date

2014-05-23

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patienten met brandwondenletsel, minimaal 6 maanden na incident. Patients with itch following burn injury

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age >= 18 years. Itch symptoms up to at least 6 months after burn injury (for patients with burn wounds only)

Exclusion criteria

Exclusion criteria: 1. Severe physical or psychological morbidity that would adversely affect participation (e.g., heart- or lung disease or DSM-IV diagnoses). 2. Use of pacemaker. 3. Pregnancy. 4. Burn wounds affecting the head (due to EEG measurements). 5. Chronic pain or itch symptoms with medical cause other than burn wounds.

Design outcomes

Primary

Measure	Time frame
This is an explorative study, investigating four different aspects of the psychoneurobiological processing of itch in patients with burn wounds and healthy controls. Since each of the four psychoneurobiological characteristics is individually relevant, the study has four different outcome measures: 1. For the sensory characteristics, visual analogue scale (VAS) scores for itch will be used as primary endpoint for the measurements for itch sensitivity as well as for the central modulation of itch (change in VAS itch). 2. For the neurobiological characteristics, individual alpha-power and peak frequency during resting state EEG as well as in response to itch stimuli (event-related EEG) will be used. 3. For the behavioral characteristics, the reaction time will be determined for the implict tests. 4. For the cognitive-affective characteristics, the total score of validated questionnaires will be used.	—

Measure

Time frame

This is an explorative study, investigating four different aspects of the psychoneurobiological processing of itch in patients with burn wounds and healthy controls. Since each of the four psychoneurobiological characteristics is individually relevant, the study has four different outcome measures: 1. For the sensory characteristics, visual analogue scale (VAS) scores for itch will be used as primary endpoint for the measurements for itch sensitivity as well as for the central modulation of itch (change in VAS itch). 2. For the neurobiological characteristics, individual alpha-power and peak frequency during resting state EEG as well as in response to itch stimuli (event-related EEG) will be used. 3. For the behavioral characteristics, the reaction time will be determined for the implict tests. 4. For the cognitive-affective characteristics, the total score of validated questionnaires will be used.

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Secondary

Measure	Time frame
The secondary endpoint is to explore the autonomic heart rate responses in response to the psychoneurobiological measurements.	—

Countries

Netherlands

Outcome results