chronic bronchitis emphysema
Conditions
Interventions
None listed
Sponsors
CIRO+, expertisecentrum voor chronisch orgaanfalen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Adults, either sex, older than 40 years of age; - Smoking history of 10 Pack Years or more; - Diagnosis of COPD stages I-IV as defined by the Global initiative for chronic Obstructive Lung Disease (GOLD); - Classified by COPD severity in group B or D, based on the GOLD criteria of COPD severity (Figure 1); - Patients must be able to complete diaries and quality of life questionnaires; - Patients must sign and date an informed consent prior to inclusion in the MCC.
Exclusion criteria
Exclusion criteria: - Progressively fatal disease, or life expectancy *6 months; - Women who are breast feeding or are pregnant; - Patients with mental conditions rendering them unable to understand the nature, scope, and possible consequences of the study; - Patients unlikely to comply with the protocol, e.g., uncooperative attitude, inability to return for follow-up visits, and unlikelihood of completing the study; - Patients participating in an intervention study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - The role of respiratory infections as pathogenic component of COPD exacerbations; - The individual response to respiratory pathogens associated with COPD exacerbations; - Determination and validation of the COPD phenotypes; - The natural history of systemic manifestations and co-morbidities of COPD and their interrelationships, associated to exacerbations; - The long-term effects of pulmonary rehabilitation; - The impact of exacerbations during pre-rehabilitation and post-rehabilitation on health outcomes; - Short- and long-term mortality. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Formation of a prospective cohort of COPD outpatients at the department of Respiratory Medicine in Maastricht. | — |
Countries
Netherlands
Outcome results
None listed