(chronische) neuropathische pijn chronic pain neuropathic pain
Conditions
Interventions
spinal anesthesia
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy male volunteers, aged 18 to 45 years, right-handed.
Exclusion criteria
Exclusion criteria: - Obesity (BMI > 30); - Significant history of any cardiac or vascular disorder, asthma or other pulmonary disease, major gastrointestinal abnormalities, peptic ulceration, hepatic, neurological, psychiatric, hematological (including bleeding disorders), endocrine, renal, or major genitourinary disease; - History of illness, condition or medication use that, in the opinion of the investigator, might interfere with optimal participation, confound the results of the study or pose additional risk in administering spinal anesthesia to the subject; - History of chronic alcohol or illicit drug use; - Metal medical devices like pacemakers, knee or hip prosthesis, ear implants, vessel clips, subcutaneous insulin pumps or carries metal particles (e.g. metal splinter in the eye) inside the body; - Claustrophobia; - Allergy to study medications; - Not able to maintain a regular diurnal rhythm.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fMRI measures (BOLD signal) pain intensity (VAS)in response to a noxious thermal stimulus reaction time after a cognitive test | — |
Secondary
| Measure | Time frame |
|---|---|
| n.v.t. | — |
Countries
Netherlands
Outcome results
None listed