Understanding and manipulating neural compensatory mechanisms in SCA3 patients

Understanding and manipulating neural compensatory mechanisms in SCA3 patients - Compensatory mechanisms in SCA3

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38791

Enrollment

Registered

2013-07-25

Start date

2014-01-24

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebellar ataxia coordination difficulties

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Proven mutation of the SCA3 gene Age > 18 years Symtomatic ataxia SARA score of gait is maximally 3 (they need to be ambulant)

Exclusion criteria

Exclusion criteria: Contraindications for MRI scanning (e.g. pacemaker, claustrofobic) Epilepsy Other neurological disorders Other gait disorders

Design outcomes

Primary

Measure	Time frame
- Changes in grey matter volume (cerebellum or other brain areas) -Changes in functional connectivity between the cerebellum and the rest of the brain -Changes in the neural circuitry that supports gait and balance We will focus on changes between patients and controls, as well as between patients before and after training	—

Countries

Netherlands

Outcome results