Trauma-focused treatment for PTSD patients with a comorbid borderline personality disorder: a feasibility study of Prolonged Exposure (PE) in an intensive format.

Trauma-focused treatment for PTSD patients with a comorbid borderline personality disorder: a feasibility study of Prolonged Exposure (PE) in an intensive format. - Treatment of PTSD in Patients with a comorbid BPD

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON38775

Enrollment

Registered

2013-11-15

Start date

2014-10-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

posttraumatic stress disorder (PTSD) and "trauma"

Interventions

Patients will receive DBT that is augmented by PE in an intensive format once the patient achieves sufficient control over (non-)suicidal self-injurious behaviour.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: General inclusion criteria of the study: - Age between 18 and 65 years - Current DSM-IV diagnosis of PTSD established with a structured diagnostic interview (CAPS-1), and a severity score of CAPS > 50. - Current DSM-IV diagnosis of BPD established with a standardized, semi structured, diagnostic interview (SCID-II), - Recent and/or imminent suicidal behavior or serious non-suicidal self-injury;Inclusion criteria to start Prolonged exposure - Not at imminent risk of suicide - No recent suicide attempts or serious non-suicidal self-injury - PTSD is the highest priority target for the patient

Exclusion criteria

Exclusion criteria: - Psychosis or delusion disorders (current or in the past) - Bipolar disorder - Substance abuse or dependence, or alcohol abuse or dependence - Mental retardation. - Insufficient ability to speak and write Dutch

Design outcomes

Primary

Measure	Time frame
- PTSD symptoms measured by the Posttraumatic Stress Symptom Scale, Self Report - Safety measured by adverse events like suicidal attempts, non-suicidal self-injury (NSSI), and crisis service use. - For treatment compliance issues, cancelled treatment appointments will be recorded throughout the DBT and PE programs, as is dropout of treatment. - PTSD symptom severity is measured with a clinician rated instrument: the Clinician-Administered PTSD Scale (CAPS-1) - Subjective ratings of improvement will be assessed with the Global Severity index (GSI)	—

Measure

Time frame

- PTSD symptoms measured by the Posttraumatic Stress Symptom Scale, Self Report - Safety measured by adverse events like suicidal attempts, non-suicidal self-injury (NSSI), and crisis service use. - For treatment compliance issues, cancelled treatment appointments will be recorded throughout the DBT and PE programs, as is dropout of treatment. - PTSD symptom severity is measured with a clinician rated instrument: the Clinician-Administered PTSD Scale (CAPS-1) - Subjective ratings of improvement will be assessed with the Global Severity index (GSI)

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Secondary

Measure	Time frame
- Severity of Borderline Personality Disorder will be assessed with the Borderline Personality Disorder Severity Index (BPDSI) - Depression will be measured with the Beck Depression Inventory-II (BDI-II) - Dissociation will be measured with the Dissociative Experiences Scale - revised version (DES-II) - Posttraumatic cognitions will be measured by the Dutch version of the Posttraumatic Cognitions Inventory (PTCI)	—

Measure

Time frame

- Severity of Borderline Personality Disorder will be assessed with the Borderline Personality Disorder Severity Index (BPDSI) - Depression will be measured with the Beck Depression Inventory-II (BDI-II) - Dissociation will be measured with the Dissociative Experiences Scale - revised version (DES-II) - Posttraumatic cognitions will be measured by the Dutch version of the Posttraumatic Cognitions Inventory (PTCI)

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)