Is post-ictal EEG suppression (PGES) in epilepsy caused by excessive cortical inhibition? Pilot study

Is post-ictal EEG suppression (PGES) in epilepsy caused by excessive cortical inhibition? Pilot study - Post-ictal EEG suppression and inhibtion

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38773

Enrollment

Registered

2013-11-26

Start date

2014-01-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy seizures

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Aged 18 years or over - Frequent seizures (any type) >1 per week - Frequent convulsive seizures (>1 per 2 months) - Recurring nocturnal seizures

Exclusion criteria

Exclusion criteria: - Pregnancy - Use or medication other than anti-epileptic drugs that alter cortical excitability (b-blockers) - performance IQ

Design outcomes

Primary

Measure	Time frame
TMS measures of cortical excitability (Motor threshold, Motor evoked potential amplitude, cortical silent period, short and long recovery curves).	—

Secondary

Measure	Time frame
Serum levels of anti-epileptic medication	—

Countries

Netherlands

Outcome results