brown adipose fat tissue insulin resistance
Conditions
Interventions
A total of 20 subjects will be included in this study. Healthy lean male
volunteers (N=10, age >18 years, BMI 19-25 kg/m2) and obese insulin resistant
male volunteers (n=10, age >18 years, BMI>25) w
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Group A; lean healthy males, age >18 years, BMI 18-25 m/kg Group B: males, age> 18 years, BMI > 25 m/kg
Exclusion criteria
Exclusion criteria: Group A: smoking, use of medication, participation in a research protcol involving radiation exposure in the last 2 year. Group B: smoking, use of medication, participation in a research protocol involving radiation exposure in the last 2 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in BAT activity (semi quantitative uptake value of the tracer FDG visualised with PET-CT) as well as insulin sensitivity (clamps) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Correlation between resting energy expenditure before and after using butyrate (4g/day, 4 weeks) during thermoneutral conditions. - Changes in fecal gutmicrobiota and fecal energy excretion (triglycerides). - Changes in subcutaneous gene and protein expression of insulin phosphorylation signalling pathways, inflammatory markers and lipid homeostasis pathways. | — |
Countries
Netherlands
Outcome results
None listed