Inhibitory Functions as Predictors of Chronic Pain: a Pilot Study

Inhibitory Functions as Predictors of Chronic Pain: a Pilot Study - Inhibition and chronic pain

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38768

Enrollment

Registered

2013-10-22

Start date

2014-06-11

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Scheduled for pancreatic resection surgery for (pre)cancer

Exclusion criteria

Exclusion criteria: • Inability to speak/understand the Dutch language. • Severe psychiatric problems • Neurodegenerative disorders • Substance abuse • History of stroke • Previous major abdominal or thoracic surgery • Current chronic pain condition

Design outcomes

Primary

Measure	Time frame
The main study outcome parameter is the presence and severity of pain, assessed with visual analogue scales, 7 to 10 days after and three months after surgery. Preoperative endogenous inhibitory functions will form the predictors of acute and persistent postoperative pain and will consist of three different measurements: 1. cognitive inhibition as measured with the Stroop taks and with the Go/No-Go task, to measure interference control and prepotent response inhibition respectively; 2. Conditioned Pain Modulation (CPM) in order to examine the extent to which a painful stimulation (cold pressor test) inhibits to experience of another painful stimulation (second PPT and EPTT, compared to the first PPT and EPTT), and; 3. Placebo- and nocebo-suggestions, to examine the extent to which expectations inhibit (placebo) or facilitate (nocebo, by diminishing inhibitory functions) pain experience.	—

Measure

Time frame

The main study outcome parameter is the presence and severity of pain, assessed with visual analogue scales, 7 to 10 days after and three months after surgery. Preoperative endogenous inhibitory functions will form the predictors of acute and persistent postoperative pain and will consist of three different measurements: 1. cognitive inhibition as measured with the Stroop taks and with the Go/No-Go task, to measure interference control and prepotent response inhibition respectively; 2. Conditioned Pain Modulation (CPM) in order to examine the extent to which a painful stimulation (cold pressor test) inhibits to experience of another painful stimulation (second PPT and EPTT, compared to the first PPT and EPTT), and; 3. Placebo- and nocebo-suggestions, to examine the extent to which expectations inhibit (placebo) or facilitate (nocebo, by diminishing inhibitory functions) pain experience.

—

Secondary

Measure	Time frame
1. Quality of life as assessed with the SF-36 2. Distress and mood ratings as assessed with visual analogue scales.	—

Countries

Netherlands

Outcome results