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Conditions
Interventions
Blue LED light exposure, LEDs fitted to glasses, of varying intensity and
varying angle of illumination. In study 1, subjects will be exposed to pulses
of 30 sec. In study 2, subjects will be expose
Sponsors
Janssen-Cilag
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy men and women; ages between 20-35y to avoid the lens changes that occur with aging Subjects should be fluent in Dutch (because of the use of Dutch rating scales). Signed informed consent.
Exclusion criteria
Exclusion criteria: You suffer from (chronic) disease (physical or psychological) You suffer from sleep disorders (mild sleep complains are not a problem) You are visually impaired or you had undergo eye surgery in the last year (contact lenses and glasses are not a problem) You are taking medication or have taken long-term effects medication in the 3 months prior to participation, which are known to increase the sensitivity to light (see leaflet) You use regular sleep medication or stimulants Two or more time zones transmeridian flights one month prior to participation Shift work during the 3 months prior to participation Colour blindness Excessive daily amounts of caffeinated drinks (>8 cups/drinks per day. E.g., coffee, cola, energy drinks) Alcohol (more than 3 glasses on a working day) or drug problems The use of melatonin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study 1: pupil size changes in response to light exposure. Study 2: melatonin suppression in response to light | — |
Secondary
| Measure | Time frame |
|---|---|
| visual comfort, alertness and performance in response to light exposure | — |
Countries
Netherlands
Outcome results
None listed