Perception of reflux and mucosal integrity in the proximal oesophagus

Perception of reflux and mucosal integrity in the proximal oesophagus - Proximal oesophageal sensitivity

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38752

Enrollment

Registered

2013-03-20

Start date

2013-07-04

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

GORD Reflux disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Patients with heartburn lasting more than 12 months • A 24-hour pH-measurement showing a symptom association probability > 95% • Written informed consent • Age 18 - 75 years

Exclusion criteria

Exclusion criteria: • Barrett*s oesophagus • History of GI cancer • GI tract surgery (except appendectomy) • Inability to stop PPI, H2-receptor antagonist or prokinetic drug for 10 days

Design outcomes

Primary

Measure	Time frame
Oesophageal sensitivity represented by the perfusion sensitivity score	—

Secondary

Measure	Time frame
• Transepithelial permeability to small molecules • Transepithelial resistance of oesophageal mucosa • Extracellular impedance measured in vivo with ETIS	—

Countries

Netherlands

Outcome results