Atopic dermatitis eczema
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. AD group: - age range 18 to 70 years - AD according to diagnostic criteria of Hanifin and Rajka - patients for APT: sensitised to aeroallergens (previously shown to have a positive APT) 2. Psoriasis group - chronic plaque psoriasis patients, ages 18-70 years
Exclusion criteria
Exclusion criteria: - topical treatment of the biopsy region with corticosteroids or tacrolimus in the two weeks prior to taking the biopsies - treatment with systemic corticosteroids or other immunosuppressive medication in the four weeks prior to taking the biopsies - exposure of biopsy location to (extraordinary) UV sunlight (e.g. UV-therapy, sunny holiday) in in the two weeks prior to taking the biopsies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will study the number of skin infiltrating cells per square millimetre skin in lesional AD skin, non-lesional AD skin, lesional psoriasis skin, non-lesional psoriasis skin and skin after atopy patch testing. This includes the analysis of: - T cells - B cells - NK cells - Dendritic cells - Eosinophils - Macrophages - Mast cells - Basophils - Neutrophils | — |
Countries
Netherlands
Outcome results
None listed