Circulating microRNAs as biomarkers in Multiple Sclerosis

Circulating microRNAs as biomarkers in Multiple Sclerosis - miRNAs in MS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38705

Enrollment

260

Registered

2013-07-23

Start date

2014-01-24

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: A diagnosis of Relapsing Remitting Multiple Sclerosis (RR-MS) according to the revised McDonald criteria, >5 years after diagnosis. (n=200) A diagnosis of Secondary Progressive Multiple Sclerosis (SP-MS) according to the revised McDonald criteria (n=30) A diagnosis of Primary Progressive Multiple Sclerosis (PP-MS) according to the revised McDonald criteria (n=30) Age 18-55 years.

Exclusion criteria

Exclusion criteria: recent diagnosis of RR-MS (low probability of converting to Secondary Progressive MS (SP-MS)).

Design outcomes

Primary

Measure	Time frame
The main study parameter is the miRNA profle in blood or CSF. The main clinical enpoint in the longitudinal study is the conversion from RR-MS to SP-MS. These data will be used to develop and validate a miRNA profile based test for the accurate identification of conversion to SPMS.	—

Secondary

Measure	Time frame
In addition analysis of observed miRNA profiles in different MS-types will provide insight in the (differences in) underlying disease mechanisms.	—

Countries

Netherlands

Outcome results