Human colon ischemia and reperfusion

Human colon ischemia and reperfusion - Colon IR

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38684

Enrollment

198

Registered

2013-11-06

Start date

2013-09-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colon ischemia/reperfusion

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Adult patients (18 years of age and older) undergoing major open colonic surgery in the MUMC+ / OMC o Right hemicolectomy o Left hemicolectomy o Low Anterior resection o Hartmann*s procedure • Patients who have given an informed consent

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study:

Design outcomes

Primary

Measure	Time frame
The primary objective of this study is to determine the pathophysiology of colonic ischemia and reperfusion in vivo in man.	—

Secondary

Measure	Time frame
* To examine cellular changes and inflammatory alterations in the human colon induced by IR. * To study the barrier function and permeability of the human colon after IR exposure. * To study the early macroscopic mucosal changes that occur as a consequence of colonic IR. * To study the consequences of human colon IR on gene expression patterns. * Identification of targets for diagnostic, preventive and therapeutic strategies. * To determine the maximum tolerable ischemia time for the colon.	—

Measure

Time frame

* To examine cellular changes and inflammatory alterations in the human colon induced by IR. * To study the barrier function and permeability of the human colon after IR exposure. * To study the early macroscopic mucosal changes that occur as a consequence of colonic IR. * To study the consequences of human colon IR on gene expression patterns. * Identification of targets for diagnostic, preventive and therapeutic strategies. * To determine the maximum tolerable ischemia time for the colon.

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Countries

Netherlands

Outcome results