Optical spectroscopy as a novel tool in the diagnostics of skin neoplasms.

Optical spectroscopy as a novel tool in the diagnostics of skin neoplasms. - Optical diagnosis of skin neoplasms.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38657

Enrollment

105

Registered

2014-01-08

Start date

2013-12-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skin cancer skin neoplasms

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Age 18 or over * Clinically suspect lesion; either actinic keratosis, squamous cell carcinoma or basal cell carcinoma * No prior treatment for the lesion * Good understanding of Dutch or English;Additional inclusion criterion for biopsy * Lesion size * 2 cm

Exclusion criteria

Exclusion criteria: * Prior treatment of the lesion * Serious other illness

Design outcomes

Primary

Measure	Time frame
Parameters that will be measured are: blood oxygen saturation, blood volume fraction, vessel diameter, melanin, beta-carotene and bilirubin concentration, autofluorescence and reduced scattering coefficient. Every parameter will be investigated for its difference between lesions and capability to predict the nature of the lesion. As a control, sun exposed or normal skin of the same subject is measured as well.	—

Measure

Time frame

Parameters that will be measured are: blood oxygen saturation, blood volume fraction, vessel diameter, melanin, beta-carotene and bilirubin concentration, autofluorescence and reduced scattering coefficient. Every parameter will be investigated for its difference between lesions and capability to predict the nature of the lesion. As a control, sun exposed or normal skin of the same subject is measured as well.

—

Secondary

Measure	Time frame
Nanostructural changes of the skin will be evaluated in 15 biopsies (5 per lesion type) using electron microscopy. Biopsy will be performed on the same site as the measurement. Electron microscopy of these biopsies will be related to the spectroscopic data.	—

Countries

Netherlands

Outcome results