narcolepsy
Conditions
Interventions
None listed
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Age: 18-60 years old - Right-handed Control group: - No current sleep, neurological or psychiatric disorder Patient groups: - Narcolepsy with cataplexy, or narcolepsy without cataplexy or idiopathic hypersomnia (without long sleep time). All disorders should have been diagnosed according to the ICSD-2 criteria. - All patients who take medications should be willing to withdraw from taking medication for 1 week.
Exclusion criteria
Exclusion criteria: - Diabetes Mellitus - (History of) clinically significant hepatic, cardiac, renal, cerebrovascular, endocrine, metabolic or pulmonary disease - Uncontrolled hypertension, defined as diastolic blood pressure at rest > 90 mmHg or systolic blood pressure at rest > 160 mmHg - (History of) clinically significant neurological or psychiatric disorders, and current psychological treatment other than narcolepsy (with/without cataplexy). - Deafness, blindness, or sensori-motor handicaps - History of taste or smell impairments - Drug, alcohol or gamble addiction in the past 6 months - Inadequate command of Dutch language - Extreme restraint eating (i.e. score restraint eating >=3.60 (females) or >= 4.00 (males) on the Dutch Eating Behavior Questionnaire; see also section 6.3.4) - Current, strict dieting (i.e. specific diet and/or in treatment with dietitian) - Food allergy to one of the ingredients used in the food rewards - Contra-indications for MRI: o Metal objects or fragments in the body that cannot be taken out o Active implants in the body o Using medical plasters o Epilepsy o Previous head surgery o Pregnancy o Claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will assess the difference in performance (i.e. error rates and reaction times) and brain activity (using fMRI) in prefrontal cortex control (i.e. attentional bias to food-related words), and striatum (i.e. food and monetary reward cue responses). | — |
Countries
Netherlands
Outcome results
None listed