migraine vasovagal syncope
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: migraine: -migraine without aura according to the IHS criteria; -baseline attack frequency of 1 to 8 attacks per 2 months; -moderate or severe headache during attacks; -age between 18 and 55 years. -female;syncope: -diagnosis of vasovagal syncope confirmed by a tilt table test - attack history must include at least 5 episodes of syncope or presyncope attacks -age between 18 and 55 years -female;migraine and syncope: -migraine without aura according to the IHS criteria; -baseline attack frequency of 1 to 8 attacks per 2 months; -moderate or severe headache during attacks; -age between 18 and 55 years. -female - diagnosis of vasovagal syncope confirmed by a tilt table test or - attack history must include at least 5 episodes of syncope or presyncopal attacks ;heathy volunteers: -age between 18-55 years -female
Exclusion criteria
Exclusion criteria: migraine: -more than 10 days of headache per month; -inability to differentiate between migraine and other forms of headache; -pregnancy; -current use of vasoactive medication; -use of more than 4 units of caffeine per day during the last 14 days; ;syncope: -inability to differentiate between vasovagal and other forms of Transient Loss of Consciousness -pregnancy -current use of vasoactive medication -age beneath 18 or above 55 years -use of more than 4 units of caffeine per day during the last 14 days;migraine en syncope: -more than 10 days of headache per month; -inability to differentiate between migraine and other forms of headache; -pregnancy; -current use of vasoactive medication; -use of more than 4 units of caffeine per day during the last 14 days; -inability to differentiate between vasovagal syncope and other forms of Transient Loss of Consciousness -age beneath 18 or above 55 years;healthy volunteers: -personal or first-degree-relative history of migraine or other primary headache syndrome, except infrequent episodic tension type headache; - personal history of VVS or any first degree relatives with vasovagal syncope -headache on > 2 days per month; -pregnancy -current use of vasoactive medication; -use of more than 4 units of caffeine per day during the last 14 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| At baseline, and during admission of NTG we will measure MAP, CO, TPR, HR, CO2 and TCD non-invasively . | — |
Secondary
| Measure | Time frame |
|---|---|
| none | — |
Countries
Netherlands
Outcome results
None listed