acute kidney injury acute renal failure
Conditions
Interventions
In the randomized controlled trial patients will be randomized to receive
standard care, i.e. prophylactic intravenous hydration before and after
intravenous iodinated contrast medium administration
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All patients aged 18 years and above, scheduled to undergo elective contrast enhanced computed tomography (no emergency department or intensive care unit) with intravenous iodinated contrast material administration. Patients with an indication for prophylactic intravenous hydration according to one of the Dutch CIN prevention guidelines will be eligible for randomization. Indication is defined as: eGFR 30-44 ml/min/1.73m2; eGFR 45-59 ml/min/1.73m2 & diabetes mellitus or * 2 risk factors; Kahler*s disease (multiple myeloma) / Waldenström*s macroglobulinemia with small chain proteinuria. Risk factors include: age >75, anaemia, use of nephrotoxic medication, cardiac or peripheral vascular disease.
Exclusion criteria
Exclusion criteria: Patients will only be included once in the RCT; no repeat inclusion for additional contrast enhanced CT examinations will occur.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint of the cohort study and randomized trial is the net number of CIN cases prevented. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoints are: cost effectiveness of screening and prevention. Health-related quality of life, complications of intravenous hydration and morbidity and mortality up to 30 days after iodinated contrast material administration. | — |
Countries
Netherlands
Outcome results
None listed