T cell function in acute hepatitis B virus infection

T cell function in acute hepatitis B virus infection - T cell function in acute HBV infection

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38638

Enrollment

Registered

2013-08-26

Start date

2013-10-10

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute liver infection with hepatitis B virus

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients that will be included are: - patients who present to the AMC or to the AMC outpatient clinic location GG&GD Amsterdam with an acute hepatitis B infection; - patients formerly diagnosed (at the AMC) with an acute HBV infection (within the last 5 years) and from whom blood samples for viral diagnostics at several time points were collected.

Exclusion criteria

Exclusion criteria: Unwillingness to donate blood and/or sign an informed consent

Design outcomes

Primary

Measure	Time frame
Primary objective: to define the immunologic and virologic signature of acute hepatitis B patients by longitudinally studying the phenotypic and functional characteristics of peripheral blood mononuclear cells (PBMC*s) and HBV viral kinetics. Patients with acute HBV infection will be compared to patients with chronic HBV infection (with high and low viral load).	—

Secondary

Measure	Time frame
Secondary objective: to investigate the mechanism of development of chronic HBV infection by comparing patients with acute HBV infection in patients clearing the HBV within 6 months versus patients who develop chronic HBV infection.	—

Countries

Netherlands

Outcome results