Long QT syndrome LQTS
Conditions
Interventions
None listed
Sponsors
Parnassia (Den Haag)
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age between 18 and 55 years. - Under treatment of the department of Anxiety Disorders, PsyQ, The Hague. - Indication to start with antidepressant medication and not known to have a contra-indication to start with this kind of medication, e.g. severe liver dysfunction, long QT-syndrome, recent myocardial infarct. - Able and willing to give informed consent.
Exclusion criteria
Exclusion criteria: - Patients who had used already antidepressant medication in the 6 weeks prior to the inclusion. - Patients who already use QT-prolonging anti-arrhythmic medication (e.g. sotalol, amiodarone). - Patients who do not meet inclusion-criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the incidence of QTc-prolongation caused by different types of antidepressants use, measured by the difference in QTc-time between baseline and after six weeks of antidepressant use within one person. | — |
Secondary
| Measure | Time frame |
|---|---|
| We investigate whether there is a difference between the different types of antidepressants (serotonin-reuptake inhibitors, serotonine-noradrenaline reuptake inhibitors, tricyclic antidepressants, mono-amine oxidase inhibitors) on the prolongation of the QTc-interval. In addition we will investigate if there are specific risk factors that contribute to this prolongation. | — |
Countries
Netherlands
Outcome results
None listed