Diverticular disease diverticulitis and diverticulosis
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Informed consent (IC) Patients undergoing a colonoscopy/sigmoidoscopy
Exclusion criteria
Exclusion criteria: Refusal of participation Inflammatory bowel disease A medical history of colorectal cancer or pre-maligmant polyp(s) Previous surgery of the colon History of familial colon cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This study aims to evaluate the possible interaction between chronic inflammation and precancerous lesions in diverticular disease. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary Objectives: Semi-quantitative scoring for * Dysplasia o No dysplasie o Indefinite for dysplasia o Low grade dysplasia o High grade dysplasia * Inflammation (active and chronic) o 0 = normal looking (round nuclei) infiltrate of the lamina propria, with a cell distribution gradient towards basal o 1= loss of gradient (because more cells are located basely) o 2 = loss of gradient and presence of neutrophil granulocytes o 3 = loss of gradient and ulceration in combination with/or presence of crypt abscesses * Apoptosis o 0 = 0 or 1 apoptotic cell per biopsy o 1 = more than 1 apoptotic cell per biopsy * Fibrosis o 0 = no fibrosis o 1 = presence of fibroses Using immunohistochemical staining, cases indefinite for dysplasia will be evaluated by * MIB1 * P53 | — |
Countries
Netherlands
Outcome results
None listed