Effects of high and low dose vitamin D on postprandial leukocyte activation, oxidative stress and vascular function in healthy overweight and obese females

Effects of high and low dose vitamin D on postprandial leukocyte activation, oxidative stress and vascular function in healthy overweight and obese females - DOSFEM

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38592

Enrollment

Registered

2013-08-28

Start date

2014-01-27

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerosis vascular function

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age of 18 years or older Pre-menopausal BMI >=25.0 kg/m2 Vitamin D deficiency (defined by a 25-hydroxyvitamin D level of

Exclusion criteria

Exclusion criteria: The use of any kind of medication except oral contraceptives Smoking Pregnancy Participation in a clinical trial less than 6 months before inclusion The use of (multi)vitamin supplements

Design outcomes

Primary

Measure	Time frame
Effect of different vitamin D doses on postprandial leukocyte activation marker CD11b	—

Secondary

Measure	Time frame
Effect of different vitamin D doses on postprandial leukocyte activation markers CD66b, CD35 and CD36, oxidative stress (lipoperoxidase) and vascular function (measured by arterial pulse wave velocity and augmentation index by pulse wave analysis)	—

Countries

Netherlands

Outcome results