Asthma carriage of resistant-bacteria COPD zoonoses
Conditions
Interventions
None listed
Sponsors
Universiteit Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: - Resident of the province of Noord-Brabant or the northern area of Limburg covered by the participating GP*s of the GP-network of NIVEL - Aged between 18 and 70 years - Living in a rural area - Giving consent on the screening questionnaire to be contacted for follow-up. Longitudinal panel study: - Non-smoker
Exclusion criteria
Exclusion criteria: Exclusion criteria Cross-sectional study: Contraindications for spirometry: Relative contraindications: - Observed minus Predicted FEV1 is below -1.5L for men and -1.2L for women - Spirometer induced airway obstruction - Use of a still active bronchodilator - Recent exacerbation of asthma or COPD, recent airway infection - Pregnancy, hypertension, epilepsy Longitudinal panel study: Exclusion criteria bronchial hyper-responsiveness (BHR) test: Absolute contraindications: - FEV1
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cross-sectional study (n=3000 (2500 + 500 controls)): All participants of the cross-sectional study will receive a questionnaire and a medical evaluation will be conducted on the participants. The main study parameters: -Respiratory health effects: pre- and post-bronchodilator lung function, atopic status (specific serum IgE to common allergens), and respiratory symptoms (questionnaire). -Zoonoses: antibodies to (respiratory) zoonotic pathogens and other pathogens that are potentially associated with livestock farming. -Resistant microorganisms: nasal MRSA carriage, ESBL-producing bacteria in faecal samples and Clostridium difficile from faecal samples. Longitudinal ESBL follow-up study (n= 25 ESBL positive patients and 25 controls): In total 25 patients who tested positive for ESBL during the cross-sectional study, will be asked for repeated samples (rectum swab). In total five repeated samples will be asked with an interval of one month. The main parameter: -Carriage of ESBL-producing bateria Longitudinal panel study (n=100 + 50 controls): Individuals included in the panel study will measure peak expiratory flow repeatedly over time and keep a symptom diary. Bronchial hyper-responsiveness will be assessed to characterize this subpopulation at one point in time. The main parameters: -Peak flow -Usage of medicines and respiratory symptoms (dairy) For all these parameters results of the air sampling and GP questionnaire data will be used to study relationships between measured emission and health effects, also taking into account distance to farming in general. Outbreak study: An adequate biological sample(s) and short questionnaire regarding among other animal (products) contact or exposure. Main parameter: -Antibodies against zoonosis | — |
Secondary
| Measure | Time frame |
|---|---|
| - | — |
Countries
Netherlands
Outcome results
None listed