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Renal Sympathetic Denervation as a Model for Studying the Influence of Hyperoxygenation and Low Salt Intake on Sympathetic Activity and Blood Pressure

Renal Sympathetic Denervation as a Model for Studying the Influence of Hyperoxygenation and Low Salt Intake on Sympathetic Activity and Blood Pressure - RHODOS Trial

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON38576
Enrollment
40
Registered
2013-06-19
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertensie high blood pressure Hypertension

Interventions

None listed

Sponsors

Academisch Medisch Centrum
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age *18 years - Indication for renal sympathetic denervation for therapy resistant hypertension - Patient is willing to participate and able to give informed consent

Exclusion criteria

Exclusion criteria: - pregnancy or planned pregnancy - planned surgery during the study period - drugs- or alcohol abuse - unable to give informed consent - actively following a caloric restricted diet for intentional weight loss

Design outcomes

Primary

MeasureTime frame
- Ambulatory blood pressure during day-time (night-time and dipping response) - Office based blood pressure—

Secondary

MeasureTime frame
- Continuous non-invasive hemodynamic recordings supine and standing (as a read-out for sympathetic nerve activity) (Nexfin device, Bmeye Amsterdam) - Plasma renin-activity (PRA), aldosteron, ANP, NT proBNP—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)