Functional magnetic resonance imaging of human hypothalamic responses to taste, temperature and glucose sensing

Functional magnetic resonance imaging of human hypothalamic responses to taste, temperature and glucose sensing - fMRI of hypothalamic response to taste, temperature and glucose sensing

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38570

Enrollment

Registered

2013-10-08

Start date

2013-11-11

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gezonde vrijwilligers healthy volunteers

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -Signed informed consent -Age between 18 and 25 years -BMI between 20 and 23 kg/m2 -Length between 170 and 190 centimeters

Exclusion criteria

Exclusion criteria: Diabetes Any genetic or psychiatric disease (e.g. fragile X syndrome, major depression) affecting brain Any significant chronic disease Renal or hepatic disease Recent weight changes or attempts to loose weight (> 3 kg weight gain or loss, within the last 3 months) Smoking (current or last 6 months) Alcohol consumption of more than 21 units per week or use of recreational drugs at present or in the last year Recent blood donation (within the last 2 months) Recent participation in other biomedical research projects (within the last 3 months), participation in 3 or more biomedical research projects in one year Contra-indication to MRI scanning

Design outcomes

Secondary

Measure	Time frame
BOLD responses in the amygdala ad nucleus accumbens Psychophysical ratings of temperature and pleasantness of taste	—

Primary

Measure	Time frame
BOLD signal intenstity changes of the hypothalamus after ingestion of 5 different stimuli (300 ml each): water at room temperature, water with ethyl-butyrate (pineapple food-flavouring) at room temperature, glucose solution at room temperature, glucose solution with ethyl-butyrate at room temperature and glucose solution with ethyl-butyrate at 0 degrees Celsius (glucose solutions contain 50 gram of glucose, ethyl-butyrate is a common food flavouring with a pineapple taste).	—

Measure

Time frame

BOLD signal intenstity changes of the hypothalamus after ingestion of 5 different stimuli (300 ml each): water at room temperature, water with ethyl-butyrate (pineapple food-flavouring) at room temperature, glucose solution at room temperature, glucose solution with ethyl-butyrate at room temperature and glucose solution with ethyl-butyrate at 0 degrees Celsius (glucose solutions contain 50 gram of glucose, ethyl-butyrate is a common food flavouring with a pineapple taste).

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Countries

Netherlands

Outcome results