Sjogren syndrome
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Sjögren syndrome patients - Primary Sjögren's syndrome diagnosed by our rheumatology departement, - >18 years;Other dry eye patients: - dry eye disease without Sjögren*s syndrome criteria (punctate keratitis or BUT18 years. ;Healthy subjects - Age >18 years - No dry eye complaints - a tear production higher than 10mm on Schirmer - Lissamine green staining score less than 5
Exclusion criteria
Exclusion criteria: Use of topical steroid eye drops, use of anti-glaucomatous eye drops, ocular surgery in the year before participation, chronic contact lens wear, history of ocular herpes keratitis. Use of immunomodulating drugs (prednison, cyclosporin);Healthy controls extra exclusion criteria will be a history of ocular disease or ocular complaints and use of artificial tears
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoint is to assess biomarkers, including anti-Ro/SSA, anti-La/SSB, BAFF, APRIL and chemokine CXCL10, in the tears of patients with primary Sjögren*s syndrome compared to that of other subjects of non Sjögren*s syndrome dry eye patients and healthy subjects. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints will be the assessment tear osmolarity in the tears of primary Sjögren*s syndrome patients in comparison to non Sjögren*s syndrome dry eye patients and healthy subjects. Furthermore, assessment of immunologic characteristics of conjunctival epithelial cells in patients with primary Sjögren*s syndrome in comparison to non Sjögren*s syndrome dry eye patients and healthy subjects. | — |
Countries
Netherlands
Outcome results
None listed