Graves Orbitopathy/Eye Disease
Conditions
Interventions
Admnistration of SOM230 (Pasireotide)
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -moderate * severe GO -corticosteroids contraindicated due to diabetes mellitus (see below), severe osteoporosis, heart failure, psychosis, infectious diseases or other clinical relevant comorbidities -corticosteroids refused by patients -age > 18
Exclusion criteria
Exclusion criteria: -inability/refusal to give informed consent -pregnancy -GO (dysthyroid optical neuropathy) necessitating high dose steroids or acute decompression -abnormal thyroid function (defined as TSH >4.0 mU/l or FT4 21 pmol/l) -pregnancy -drug abuse and smoking.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Predefined combined clinical endpoints: see protocol. | — |
Secondary
| Measure | Time frame |
|---|---|
| n.a. | — |
Countries
Netherlands
Outcome results
None listed