type 2 diabetes
Conditions
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Group 1 (n25 kg/m2 - habitual wake-up time between 6:00 and 9:00 - no DM2: fasting venous plasma glucose 25 kg/m2 - habitual wake-up time between 6:00 and 9:00 - type 2 diabetes: fasting venous plasma glucose >6.9 mmol/l or HbA1c > 6.5%
Exclusion criteria
Exclusion criteria: - use of any other medication than metformin that interferers with glucose metabolism or neuronal synaptic transmission (corticosteroids, anti-depressants, anti-epileptic medication, other psychotropic drugs, anti malarials) - gastro-intestinal or metabolic disease that will interfere with digestion or metabolism - neuropsychiatric illness including severe depression - epilepsy - hypertension - ophthalmological abnormalities (e.g. retinopathy) - lactose intolerance - soy allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postprandial glucose excursions, and expression of metabolic genes in adipose tissue. | — |
Secondary
| Measure | Time frame |
|---|---|
| - postprandial insulin excursions - postprandial free fatty acid (FFA) excursions - postprandial triglyceride levels - morning glucocorticoid increase - morning salivary melatonin decrease - resting energy expenditure (REE) - measurements of autonomic balance: - skin temperature decrease - heart rate variability - hunger and satiety ratings - clock gene expression in leucocytes | — |
Countries
Netherlands
Outcome results
None listed