The role of skin autofluorescence as a predictor for post-operative proliferative vitreoretinopathy and surgical failure in patients with retinal detachment

The role of skin autofluorescence as a predictor for post-operative proliferative vitreoretinopathy and surgical failure in patients with retinal detachment - Skin autofluorescence and surgical failure in retinal detachment patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38541

Enrollment

500

Registered

2013-08-07

Start date

2013-11-11

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

(rhegmatogenous) retinal detachment

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Willingness to participate. • Patients, diagnosed with retinal detachment, scheduled for vitrectomy. • Age: >18 years.

Exclusion criteria

Exclusion criteria: • Dark coloured skin (Fitzpatrick type V or VI). • Skin abnormalities on both arms that will impair the reliability of the autofluorescence measurement. • Local or general active infection or inflammatory disease. • Known renal disease with impairment of renal function class CKD >=3 (

Design outcomes

Primary

Measure	Time frame
- The relation between skin AF and failure of surgery for retinal detachment - The relations between skin AF and PVR (pre- and postoperative), vitreous body AGE and sRAGE levels, plasma sRAGE levels and glyoxalase and RAGE polymorphisms.	—

Secondary

Measure	Time frame
Relation between surgical failure and clinical risk factors for post-operative PVR.	—

Countries

Netherlands

Outcome results