Determination of complement binding HLA-C antibodies with single-antigen-expressing cell lines (SAL) in pregnancies complicated by preeclampsia

Determination of complement binding HLA-C antibodies with single-antigen-expressing cell lines (SAL) in pregnancies complicated by preeclampsia - Complement binding HLA-C antibodies in preeclampsia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38539

Enrollment

132

Registered

2013-06-17

Start date

2013-07-01

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy toxicosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: We select primiparous women with an uncomplicated, term pregnancy (control) and preeclampsia (case) who deliver at the Leiden University Medical Center. Preeclampsia is defined as gestational hypertension (systolic pressure >= 140 mmHg and/or diastolic pressure >= 90 mmHg detected after 20th week of gestation) or worsening of preexistent hypertension and proteinuria (>= 0.3 gr/l/24hours).

Exclusion criteria

Exclusion criteria: Maternal autoimmune diseases as antiphospholipid syndrome or SLE, drugs, use of immunosuppressive medication, intrauterine infections and bloodtransfusions or organ transplantions in medical history.

Design outcomes

Primary

Measure	Time frame
Presence of HLA-C IgG1 and/or IgG3	—

Secondary

Measure	Time frame
Presence of HLA-C IgG and IgM Presence of HLA class I and II antibodies	—

Countries

Netherlands

Outcome results