Post-polio syndrome
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: PPS patients: Subject has symptomatic quadriceps deterioration, evidence of enlarged motor units (as measured by high-density surface EMG) and isometric quadriceps muscle strength of >=30Nm in at least one leg. Subject has symptoms for >= 1 year that cannot be explained by any other neurological disorder Healthy controls: Subject is free of symptoms that can be explained by any neurological disorder
Exclusion criteria
Exclusion criteria: PPS patients & healthy controls: Subject is unwilling or unable to participate in this study and to give informed consent. Subject is also excluded if prosthesis registration number cannot be acquired (relatively new prostheses are not a contra-indication for MRI, this can be checked with the prosthesis registration number) (If applicable). Other exclusion criteria are contra-indications to undergo an MRI scan (pregnancy, claustrophobia, metal corpora aliena or metal implants such as pacemakers)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study endpoint will be a characterization of changes in DTI parameters of affected muscles, isometric muscle strength measurements (quadriceps) and a full picture of the architectural organization of lower limb muscles and the leg as a whole. | — |
Countries
Netherlands
Outcome results
None listed