Comparison of the effects of atropine on haemodynamics and tissue oxygenation in anaesthesia with propofol and sufentanil versus propofol and remifentanil.

Comparison of the effects of atropine on haemodynamics and tissue oxygenation in anaesthesia with propofol and sufentanil versus propofol and remifentanil. - Atropine effects in anaesthesia with Sufentanil vs. Remifentanil.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON38529

Enrollment

Registered

2013-03-05

Start date

2013-06-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CABG Open Heart Surgery

Interventions

Patients will be randomised to receive anaesthesia with propofol and an equipotent effect site concentration of either sufentanil or remifentanil administered with target controlled infusion pumps.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age: 18 years and older -- Written informed consent to participate in this study. - Elective CABG surgery performed off-pump. - Patient and surgical procedure appropriate for treatment with either sufentanil or remifentanil.

Exclusion criteria

Exclusion criteria: - Refusal to participate in this study. - Age: younger than 18 years. - Pregnant. - BMI > 35 kg/m2. - Patients in which atropine is contra-indicated. - Patients in which sufentanil or remifentanil at the proposed doses are contra-indicated. - Urgent or emergency surgery.

Design outcomes

Primary

Measure	Time frame
The change in CO (continuous measurement of the Nexfin monitor) around the moment of atropine administration.	—

Secondary

Measure	Time frame
The evolution of MAP, SctO2 and SptO2 around the moment of atropine administration.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)