The Red Blood Cell in Patients with Neuroacanthocytosis: an explorative study on regulation of morphology and function of red blood cells of patients with neurodegeneration of the basal ganglia.

The Red Blood Cell in Patients with Neuroacanthocytosis: an explorative study on regulation of morphology and function of red blood cells of patients with neurodegeneration of the basal ganglia. - RBC-EMINA

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38521

Enrollment

Registered

2014-01-30

Start date

2013-09-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

neuroacanthocytosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: control donors: healthy, 18-55 years old patients: clinical diagnosis neuroacanthocytosis

Exclusion criteria

Exclusion criteria: controls: use of medication with a known effect on red blood cells structure and/or function patients: inability to obtain sufficient data for a clinical diagnosis

Design outcomes

Primary

Measure	Time frame
The main study parameters are characteristics of red blood cell structure and function in vitro: A. deformability in capillary flow conditions. B. deformability in spleen-like conditions. C. cell morphology. D. cell membrane composition. E. metabolic status. F. characteristics and kinetics of erythropoiesis in vitro. G. active signaling pathways.	—

Countries

Netherlands

Outcome results