Changes in middle cerebral artery blood flow velocity during the early phase of fluid resuscitation in septic intensive care patients

Changes in middle cerebral artery blood flow velocity during the early phase of fluid resuscitation in septic intensive care patients - MCA blood flow velocity in septic patients during fluid resuscitation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38500

Enrollment

Registered

2013-03-11

Start date

2013-06-18

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

blood-poisoning or septicemia sepsis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: ICU patient in Martini hospital Groningen Diagnosed sepsis; either severe sepsis or septic shock Noradrenaline dependency at ICU admission Pulmonary artery catheter in situ

Exclusion criteria

Exclusion criteria: Younger than 18 years Absence of relatives who can give informed consent on behalf of the temporarily incapacitated subject Insufficient temporal window for TCD investigation Life expectance of less than 2 days at ICU admission Intracranial infection Pre-existing brain injury Pre-existing cardiac insufficiency Immune compromised

Design outcomes

Primary

Measure	Time frame
The main study parameter is the change in blood flow velocity in the MCA measured by TCD as a result of initial fluid resuscitation. The study is ended when 16 subjects, in whom written consent has been obtained, have successfully completed the entire study.	—

Secondary

Measure	Time frame
The secondary study parameter is the fluid responsiveness. This is determined by the gold standard for cardiac output determination, namely a thermodilution measurement by means of an in situ pulmonary artery catheter. Other study parameters which might intervene with the main study parameter are the blood pressure, heart frequency and CO2 level.	—

Countries

Netherlands

Outcome results