Pilot study of measuring cardiac volume and cardiac function in patients with resectable esophagus carcinoma during pre-operative chemoradiation

Pilot study of measuring cardiac volume and cardiac function in patients with resectable esophagus carcinoma during pre-operative chemoradiation - Deltastudy chemoradiation esophageal carcinoma

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38490

Enrollment

Registered

2013-02-20

Start date

2013-04-25

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

esophageal cancer

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: patients with esophageal cancer who are planned to be treated with preoperative chemoradiation

Exclusion criteria

Exclusion criteria: cardiac failure NYHA class 3 and 4 previous radiotherapy

Design outcomes

Primary

Measure	Time frame
Change in cardiac volume at baseline compared to weekly measurement during chemoradiation	—

Secondary

Measure	Time frame
- Change in inferior vena cava diameter at the end of chemoradiation compared to baseline - Changes in myocardial strain and strain rate at the end of chemoradiation compared to baseline - Weekly changes in concentration of Creatine Kinase (CK), Creatine Kinase Muscle type and Brain type (CK-MB), troponin, N-terminal-pro-natriuretic peptide (NT-pro-BNP) - Change in LVEF at the end of chemoradiation compared to baseline - Change in New York Heart Association (NYHA) score at baseline compared to weekly measurements during treatment. *	—

Measure

Time frame

- Change in inferior vena cava diameter at the end of chemoradiation compared to baseline - Changes in myocardial strain and strain rate at the end of chemoradiation compared to baseline - Weekly changes in concentration of Creatine Kinase (CK), Creatine Kinase Muscle type and Brain type (CK-MB), troponin, N-terminal-pro-natriuretic peptide (NT-pro-BNP) - Change in LVEF at the end of chemoradiation compared to baseline - Change in New York Heart Association (NYHA) score at baseline compared to weekly measurements during treatment. *

—

Countries

Netherlands

Outcome results