nierfalen waarvoor niertransplantatie ESBL urinary tract infections and ESBL colonisation
Conditions
Interventions
Donor feces infusion.
Sponsors
Academisch medisch centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Renal transplant recipients colonised by ESBL producing Entrobacteriaceae in the large intestine. Stable renal allograft function with maintenance dose of immunosuppressive therapy. No food allergies.
Exclusion criteria
Exclusion criteria: 1: Patients with ESBL strain in urine which is resistant to first line antibiotics (as nitrofurantoin) 2: Patients still being ESBL positive in throat or urine despite pre-treatment with chlorhexidin or first line antibiotic (as nitrofurantoin). 3: Experiencing rejection episode which require high dose immune-suppressants or critically ill recipients admitted to the ICU. 4: Signs of diminished bowel passage or ileus 5: Recent endoscopy with biopsies within last three months 6: Pregnancy 7: Known food allergie to any kind of food products. 8: Heavily immunocompromised patients ( prednisone use of > 60 mg per day or CD4 count
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome is ESBL decolonisation of the rectum after 12 weeks post donor feces infusion. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1: Development of ESBL related urinary tract infection within 24 weeks follow-up time after donor feces infusion. 2: Changes in microbiome prior and after donor feces infusion. | — |
Countries
Netherlands
Outcome results
None listed