Confirming the pharmacological interaction between colchicine and 18F-choline PET

Confirming the pharmacological interaction between colchicine and 18F-choline PET - Interaction between colchicine and choline PET

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON38465

Enrollment

Registered

2013-12-11

Start date

2014-01-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prostate cancer

Interventions

After the routine FCH-PET scan, an addition FCH-PET will be performed with premedication 1 mg colchicine per os.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Histopathologically proven prostate cancer - Suspected of disease recurrence because of PSA relapse - Scheduled for routine FCH-PET for restaging

Exclusion criteria

Exclusion criteria: - Age

Design outcomes

Primary

Measure	Time frame
The main study parameter is the uptake of FCH, as seen on PET, in the presence and absence of colchicine. The main study endpoint is the presence of an interaction, defined as colchicine induced absence of FCH transport from blood to tissues.	—

Secondary

Measure	Time frame
SUVmean of FCH uptake in various tissues, including e.g. tumor, liver, muscle, bone marrow and blood.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)