7T Sodium MRI of healthy and osteoarthritic cartilage of the knee

7T Sodium MRI of healthy and osteoarthritic cartilage of the knee - 7T sodium MRI of cartilage

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON38455

Enrollment

200

Registered

2014-04-02

Start date

2014-10-31

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

degenerative joint disease Osteoarthritis wear and tear of the joint

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients: people who are selected for knee joint replacement Age-matched controls: people who are OA symptom free Healthy volunteers: people who are OA symptom free

Exclusion criteria

Exclusion criteria: Contra-indications for 7T MRI scanning No consent No family

Design outcomes

Primary

Measure	Time frame
1) A curve that describes normal sodium concentration in knee cartilage over a broad age range. This curve a a normal curve that can be used to detect early OA using sodium-MRI. 2) Fundamental insight into the mechanism of OA and cartilage degeneration by comparing sodium concentrations in cartilage in different pools (bound to PG and free in solution). 3) Development of a gold standard for sodium concentration measurements in vivo in cartilage by comparing sodium-MRI with ex vivo concentration measurements of post-surgery obtained cartilage.	—

Measure

Time frame

1) A curve that describes normal sodium concentration in knee cartilage over a broad age range. This curve a a normal curve that can be used to detect early OA using sodium-MRI. 2) Fundamental insight into the mechanism of OA and cartilage degeneration by comparing sodium concentrations in cartilage in different pools (bound to PG and free in solution). 3) Development of a gold standard for sodium concentration measurements in vivo in cartilage by comparing sodium-MRI with ex vivo concentration measurements of post-surgery obtained cartilage.

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Secondary

Measure	Time frame
If the primary outcomes are of sufficient quality then these techniques can be used for the development of new OA treatments.	—

Countries

Netherlands

Outcome results