hearing impairment single-sided deafness
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Patients aged 18 or older. - Normal function of middle ear (i.e. no acute middle ear infections or tympanic membrane perforations). Air bone gap (reflecting middle-ear function) = 70 dB HL. - Hearing in *normal* ear: hearing threshold for individual frequencies (0.5, 1, 2, 4 kHz)
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Abnormal cochlear anatomy in one or both ears (i.e. ossification). - Disability which could interfere with the completion of the tests (i.e. psychiatric problems or severe co-morbidity with an expected survival of less than five years). - Patients with contraindications for Magnetic Resonance Imaging (MRI) - Not fulfilling the criteria of the MRI inclusion list (see file F), including the presence of any type of metal in the body, tattoos on the skin and pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoint of this study is the difference between the normal auditory nerve and degenerated auditory nerve. The difference can be quantified with the diffusion parameters fractional anisotropy (FA), apparent diffusion coefficient (ADC), axial diffusivity (AD) and radial diffusivity (RD). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secundary endpoint of the study is the comparison between the normal nerve in SSD patients and the normal nerve in healthy controls. | — |
Countries
Netherlands
Outcome results
None listed